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KMID : 1123920110250050830
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 5 p.830 ~ p.836
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Synergic Effect of Quercetin and Astragalin from Mulberry Leaves on Ani-inflammation
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Mok Ji-Ye
Jeong Seung-Il
Kim Jang-Ho
Jang Seon-Il
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Abstract
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The leaf of mulberry (Morus alba L) has long been used in Oriental medicine for the prevention or treatment of several diseases. However, little is known about the inhibitory effects of a single compound isolated from the mulberry leaves on inflammatory response. We are isolate a single compound of quercetin (3,3’,4’,5,7-pentahydroxyflavone) and astragalin (kaempferol-3-O-glucopyranoside) from the mulberry leaves, and then investigate the anti-inflammatory effects of quercetin, astragalin or quercetin plus astragalin in lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages. Each compound suppressed the production of inflammatory mediators (NO, PGE2 and IL-6) in LPS-stimulated murine peritoneal macrophages in a dose-dependent manner. Especially, the cotreatment of quercetin (2.5 ㎛) and astragalin (2.5 ㎛) markedly suppressed the production and the expression of inflammatory mediators. These suppressive effects were synergistically increased by their combination. These results suggest that the combination of quercetin and astragalin from the mulberry leaves may be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
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KEYWORD
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Mulberry(Morus alba L.) leaves, quercetin, astragalin, anti-inflammation, synergic effect
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